?近日,在《Arterioscler Thromb Vasc Biol》發(fā)表的最新文章“Maternal Inheritance of Familial Hypercholesterolemia Gene Mutation Predisposes to Coronary Atherosclerosis as Assessed by Calcium Score in Adulthood”中,研究人員對(duì)1350例FH患者進(jìn)行單變量和多變量分析,以評(píng)估FH基因突變的親代遺傳對(duì)CAC(冠狀動(dòng)脈鈣化)評(píng)分的個(gè)體影響。結(jié)果表明母系遺傳的FH基因突變與更嚴(yán)重的亞臨床冠狀動(dòng)脈粥樣硬化相關(guān),可能被認(rèn)為是FH女性后代的一個(gè)潛在的心血管危險(xiǎn)因素。